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The emerging role of human papillomavirus in lung cancer.

Authors :
Parama D
BharathwajChetty B
Jayaprakash S
Lee EHC
Khatoon E
Alqahtani MS
Abbas M
Kumar AP
Kunnumakkara AB
Source :
Life sciences [Life Sci] 2024 Aug 15; Vol. 351, pp. 122785. Date of Electronic Publication: 2024 Jun 06.
Publication Year :
2024

Abstract

Lung cancer stands as one of the most lethal diseases and is the foremost cause of cancer-related mortalities worldwide. The pathophysiology of lung cancer is multifaceted, and it includes multiple cell signaling pathways and other complex factors such as oxidative stress and genetics. The association of HPV with lung carcinogenesis was first proposed in 1979, and since then, scientists worldwide have been putting forward several hypotheses to establish a relationship between this virus and lung cancer. Although studies have reported the presence of HPV in lung cancer, the exact mechanism of entry and the route of transmission have not been elucidated clearly till date. Numerous studies across the globe have detected differentially expressed HPV oncoproteins in lung cancer patients and found their association with the critical cell signaling pathways that leads to the development and progression of lung cancer. Many reports have also provided evidence stating the involvement of HPV in determining the survival status of lung cancer patients. The present review recapitulates the studies evincing the association of HPV and lung cancer, its route of transmission and mechanism of action; the detection of the virus and treatment opportunities for HPV-positive lung cancer; and the severity associated with this disease. Therefore, this will provide an explicit idea and would help to develop preventive measures and specific as well as effective treatment for HPV-associated lung carcinogenesis.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1879-0631
Volume :
351
Database :
MEDLINE
Journal :
Life sciences
Publication Type :
Academic Journal
Accession number :
38851420
Full Text :
https://doi.org/10.1016/j.lfs.2024.122785