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Prognosis of microscopic polyangiitis is well predictable in the first 2 weeks of treatment.
- Source :
-
Clinical and experimental nephrology [Clin Exp Nephrol] 2024 Jul; Vol. 28 (7), pp. 701-706. Date of Electronic Publication: 2024 Jun 08. - Publication Year :
- 2024
-
Abstract
- Background: Kidney and life outcomes remain unsatisfactory in patients with microscopic polyangiitis (MPA). Appropriate treatment intensity must be provided to the appropriate patients. To identify severe cases early, we investigated the factors related to kidney and life outcomes.<br />Methods: We included patients diagnosed with MPA based on myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) positivity and kidney histopathology results after kidney biopsies between January 1, 2021, and May 11, 2023, at 10 affiliated centers, including our hospital. Death, maintenance dialysis, and estimated glomerular filtration rate (eGFR) < 15 after 6 months of treatment were defined as poor prognosis groups, and factors associated with these conditions were investigated.<br />Results: We included 84 (36 men and 48 women) patients in this study. Median age was 73.8 (interquartile range: 71-81) years. After 6 months of treatment, the proportion of patients in the poor prognosis group was 16.7 %, with a mortality of 7.1 % and a poor kidney prognosis rate of 9.5 %. Area under the receiver operating characteristic curve showed that eGFR at 2 weeks had a comparable prognostic performance equal as eGFR at 4 weeks (area under the curve: 0.875 and 0.896, respectively). After adjustment by various factors, eGFR at 2 weeks was related with prognosis significantly (p = 0.031).<br />Conclusion: Kidney function 2 weeks after the start of treatment for MPA can predict prognosis.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Aged
Aged, 80 and over
Prognosis
Time Factors
Retrospective Studies
Kidney pathology
Kidney physiopathology
Peroxidase immunology
Immunosuppressive Agents therapeutic use
Renal Dialysis
Treatment Outcome
Microscopic Polyangiitis drug therapy
Microscopic Polyangiitis mortality
Microscopic Polyangiitis diagnosis
Glomerular Filtration Rate
Antibodies, Antineutrophil Cytoplasmic blood
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7799
- Volume :
- 28
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical and experimental nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 38851645
- Full Text :
- https://doi.org/10.1007/s10157-024-02522-6