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Genetic polymorphisms linked to extreme postorthodontic external apical root resorption in Koreans.
- Source :
-
Progress in orthodontics [Prog Orthod] 2024 Jun 10; Vol. 25 (1), pp. 23. Date of Electronic Publication: 2024 Jun 10. - Publication Year :
- 2024
-
Abstract
- Background: External apical root resorption (EARR) is a common undesirable outcome of orthodontic treatment, this study aimed to identify genetic polymorphisms associated with the susceptibility to extreme orthodontic-induced EARR in a Korean population using extreme phenotype analysis sampling.<br />Methods: Genomic DNA was isolated from the saliva of 77 patients who underwent orthodontic treatment involving two maxillary premolar extractions. The patients were divided into two groups based on EARR values measured on periapical radiographs: The significant resorption group (SG, EARR ≥ 4 mm) and the normal group (NG, EARR < 2 mm). In the NG group, patients with EARR < 1 mm were named the non-resorption group (NonG). Targeted next-generation sequencing was performed using the screened single nucleotide polymorphisms (SNPs), and firth logistic regression analysis was used to determine genetic associations with EARR. Haplotype-based association analysis was performed for specific SNPs.<br />Results: SNPs related to genes TNFSF11, TNFRSF11B, WNT3A, SFRP2, LRP6, P2RX7, and LRP1 were found to be significantly associated with severe EARR (p < 0.05, pre-Bonferroni correction p-values). Additionally, the haplotype CCA of rs17525809, rs208294, and rs1718119 P2RX7 had a higher frequency in the SG group.<br />Conclusion: Extreme phenotype analysis has identified eleven SNPs related to genes TNFSF11, TNFRSF11B, WNT3A, SFRP2, LRP6, P2RX7, and LRP1 that are associated with severe root resorption in the Korean population. These findings will contribute to the development of predictive diagnostic tools for identifying severe root resorption that may occur during orthodontic treatment.<br /> (© 2024. The Author(s).)
- Subjects :
- Adolescent
Female
Humans
Male
Young Adult
Asian People genetics
East Asian People
Genetic Predisposition to Disease
Haplotypes
Orthodontics, Corrective
Osteoprotegerin genetics
Phenotype
RANK Ligand
Receptors, Purinergic P2X7 genetics
Republic of Korea
Polymorphism, Single Nucleotide
Root Resorption genetics
Root Resorption diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2196-1042
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Progress in orthodontics
- Publication Type :
- Academic Journal
- Accession number :
- 38853224
- Full Text :
- https://doi.org/10.1186/s40510-024-00521-7