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Etomidate alleviates ovarian ischemia-reperfusion injury in rats.
- Source :
-
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES [Ulus Travma Acil Cerrahi Derg] 2024 Jun; Vol. 30 (6), pp. 375-381. - Publication Year :
- 2024
-
Abstract
- Background: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury.<br />Methods: A total of 24 female rats were randomized into three groups. Group 1 served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflammatory cytokine levels, and antioxidant enzyme activity RESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-1 Beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in Group 3 compared to Group 2 (p=0.005, p=0.016, and p<0.001, respectively). Additionally, a decrease in malondialdehyde (MDA) levels was observed in Group 3 compared to Group 2 (p<0.001). In contrast, activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased in Group 3 compared to Group 2 (p=0.031 and p=0.001, respectively). Furthermore, Group 3 demonstrated notable reductions in histopathological scores for follicular degeneration, vascular occlusion, bleeding, and inflammation compared to Group 2 (p<0.001, p<0.001, p<0.001, and p=0.001, respectively).<br />Conclusion: Etomidate alleviates ischemia-reperfusion injury in a rat ovarian torsion-detorsion model by improving both histopathological and biochemical outcomes.
- Subjects :
- Animals
Female
Rats
Ovarian Torsion drug therapy
Disease Models, Animal
Malondialdehyde blood
Ovary drug effects
Ovary blood supply
Ovary pathology
Oxidative Stress drug effects
Lipid Peroxidation drug effects
Superoxide Dismutase metabolism
Superoxide Dismutase blood
Antioxidants pharmacology
Random Allocation
Reperfusion Injury drug therapy
Reperfusion Injury prevention & control
Etomidate pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1307-7945
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
- Publication Type :
- Academic Journal
- Accession number :
- 38863285
- Full Text :
- https://doi.org/10.14744/tjtes.2024.27388