Central trained immunity and its impact on chronic inflammatory and autoimmune diseases.

Competing Interests: Disclosure statement Supported by the National Instituters of Health (grants DE031206 and DE033643 [to G.H.]), the Deutsche Forschungsgemeinschaft (Collaborative Research Centre TRR369, project C03, and Collaborative Research Centre TRR332, project B03 [to T.C.]), the European Research Council (to T.C.), the Exzellenzförderprogramm für etablierte Wissenschaftlerinnen und Wissenschaftler (German Cancer Aid [to T.C.]), and the the Saxon State Ministry of Science, Culture and Tourism- Sonderzuweisung zur Unterstützung profilbestimmender Struktureinheiten der TUD [to T.C.]). Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.