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Delirium due to Trousseau syndrome treated with memantine and perospirone: A case report.

Authors :
Yamaguchi J
Hirayama T
Sadahiro R
Nakahara R
Matsuoka H
Source :
PCN reports : psychiatry and clinical neurosciences [PCN Rep] 2023 Nov 16; Vol. 2 (4), pp. e159. Date of Electronic Publication: 2023 Nov 16 (Print Publication: 2023).
Publication Year :
2023

Abstract

Background: Trousseau syndrome is a hypercoagulability syndrome associated with cancer. It is known that delirium occasionally occurs after the onset of Trousseau syndrome. However, there have been no detailed reports about treatment for psychiatric symptoms of delirium associated with Trousseau syndrome.<br />Case Presentation: A 61-year-old man with lung cancer was hospitalized due to Trousseau syndrome. Delirium occurred after hospitalization and psychiatric symptoms worsened. Although haloperidol, risperidone, and chlorpromazine were used, severe insomnia persisted. After memantine (5 mg/day) was used with perospirone, the patient's psychiatric symptoms gradually decreased; he could sleep for 4-5 h at night. Due to psychiatric improvement, he was able to return home and resume immunotherapy for lung cancer as scheduled.<br />Conclusion: We report the first case of Trousseau syndrome delirium treated by memantine used with perospirone. Although further studies are needed, memantine and perospirone might be candidates for the management of psychiatric symptoms associated with Trousseau syndrome.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2023 The Authors. Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.)

Details

Language :
English
ISSN :
2769-2558
Volume :
2
Issue :
4
Database :
MEDLINE
Journal :
PCN reports : psychiatry and clinical neurosciences
Publication Type :
Academic Journal
Accession number :
38868734
Full Text :
https://doi.org/10.1002/pcn5.159