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Molecular epidemiology and risk factors associated with BK and JC polyomavirus urinary shedding after kidney allograft.
- Source :
-
Journal of medical virology [J Med Virol] 2024 Jun; Vol. 96 (6), pp. e29742. - Publication Year :
- 2024
-
Abstract
- Polyomaviruses BK (BKPyV) and JC (JCPyV), belonging to the Polyomaviridae, are responsible for human pathologies. In kidney transplant recipients, BKPyV replication can lead to irreversible nephron damage whereas JCPyV replication remains asymptomatic. Concomitant replication is rare and potential competition between the infections has been described. The aim of this retrospective case-control study was to describe the molecular epidemiology and risk factors associated with BKPyV and JCPyV replication in a cohort of kidney transplant recipients. In total, 655 urine samples from 460 patients were tested for BKPyV and JCPyV DNA. Positive samples were submitted to strain genotyping. Demographic and clinical characteristics were also compared. Isolated JCPyV and BKPyV was found in 16.5% and 23.3% of patients, respectively; co-replication was rare (3.9%). BKPyV strains Ib-2, Ib-1, and IVc-2 were the most prevalent. JCPyV strains mostly belonged to genotypes 4 and 1B. During follow-up, JCPyV shedding significantly reduced the risk of BKPyV DNAuria, with an odds ratio of 0.57 (95% confidence interval: 0.35-0.99), and was associated with better prognosis than BKPyV replication, based on the estimated glomerular filtration rate. Molecular epidemiology of BKPyV and JCPyV strains in our region was similar to previous studies. This study suggests that JCPyV is benign and appears to limit damaging BKPyV replication. JCPyV DNAuria screening could thus be a useful strategy to predict BKPyV-related outcomes.<br /> (© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)
- Subjects :
- Humans
Male
Female
Middle Aged
Retrospective Studies
Risk Factors
Case-Control Studies
Adult
Virus Shedding
Aged
Transplant Recipients statistics & numerical data
Tumor Virus Infections epidemiology
Tumor Virus Infections virology
Tumor Virus Infections urine
DNA, Viral urine
DNA, Viral genetics
Allografts virology
BK Virus genetics
BK Virus isolation & purification
Polyomavirus Infections epidemiology
Polyomavirus Infections virology
Polyomavirus Infections urine
Kidney Transplantation adverse effects
JC Virus genetics
JC Virus isolation & purification
Genotype
Molecular Epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9071
- Volume :
- 96
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of medical virology
- Publication Type :
- Academic Journal
- Accession number :
- 38874263
- Full Text :
- https://doi.org/10.1002/jmv.29742