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Effects of antidepressants on brain structure and function in patients with obsessive-compulsive disorder: A review of neuroimaging studies.
- Source :
-
Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2024 Aug; Vol. 342, pp. 111842. Date of Electronic Publication: 2024 Jun 06. - Publication Year :
- 2024
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Abstract
- Obsessive-compulsive disorder (OCD) affects 2-3% of people worldwide. Although antidepressants are the standard pharmachological treatment of OCD, their effect on the brain of individuals with OCD has not yet been fully clarified. We conducted a systematic search on PubMed, Scopus, Embase, and Web of Science to explore the effects of antidepressants on neuroimaging findings in OCD. Thirteen neuroimaging investigations were included. After antidepressant treatment, structural magnetic resonance imaging studies suggested thalamic, amygdala, and pituitary volume changes in patients. In addition, the use of antidepressants was associated with alterations in diffusion tensor imaging metrics in the left striatum, the right midbrain, and the posterior thalamic radiation in the right parietal lobe. Finally, functional magnetic resonance imaging highlighted possible changes in the ventral striatum, frontal, and prefrontal cortex. The small number of included studies and sample sizes, short durations of follow-up, different antidepressants, variable regions of interest, and heterogeneous samples limit the robustness of the findings of the present review. In conclusion, our review suggests that antidepressant treatment is associated with brain changes in individuals with OCD, and these results may help to deepen our knowledge of the pathophysiology of OCD and the brain mechanisms underlying the effects of antidepressants.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Magnetic Resonance Imaging
Obsessive-Compulsive Disorder drug therapy
Obsessive-Compulsive Disorder diagnostic imaging
Obsessive-Compulsive Disorder physiopathology
Obsessive-Compulsive Disorder pathology
Antidepressive Agents therapeutic use
Antidepressive Agents pharmacology
Neuroimaging methods
Brain diagnostic imaging
Brain drug effects
Brain pathology
Brain physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7506
- Volume :
- 342
- Database :
- MEDLINE
- Journal :
- Psychiatry research. Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 38875766
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2024.111842