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Metabolic syndrome parameters' variability and stroke incidence in hypertensive patients: evidence from a functional community cohort.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Jun 15; Vol. 23 (1), pp. 203. Date of Electronic Publication: 2024 Jun 15. - Publication Year :
- 2024
-
Abstract
- Background: Stroke is a common complication of hypertension, but the predictive value of metabolic syndrome parameters' variability on stroke risk in individuals with hypertension remains unclear. Therefore, our objective was to investigate the relationship between metabolic syndrome parameters' variability and the risk of total stroke and its subtypes in hypertensive patients.<br />Methods: This prospective cohort study included 17,789 individuals with hypertension from the Kailuan study since 2006. Metabolic syndrome parameters, including waist circumference (WC), fasting blood glucose (FBG), systolic blood pressure (SBP), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG), were collected at three follow-up visits in the 2006, 2008, and 2010 surveys. We assess the variability utilizing the coefficient of variation (CV), standard deviation (SD), average real variation (ARV), and variability independent of the mean (VIM), with CV initially assessed. Participants were categorized based on the number of high-variability metabolic syndrome parameters (0, 1, 2, ≥ 3). Stroke cases were identified by reviewing medical records. The associations between variability in metabolic syndrome parameters and the risk of total stroke and its subtypes were analyzed using Cox proportional hazard regression models.<br />Results: During a median follow-up of 9.32 years, 1223 cases of stroke were recorded. Participants with ≥ 3 high-variability metabolic syndrome parameters had an increased risk of total stroke (HR: 1.29, 95%CI 1.09-1.52), as well as an increased risk of ischemic stroke (HR: 1.31, 95%CI 1.05-1.63) compared to those without high-variability parameters. The study also examined variability in each metabolic syndrome parameter, and significant associations with an increased risk of total stroke were observed for variability in SBP (HR: 1.24, 95%CI 1.05-1.46) and HDL-C (HR: 1.34, 95%CI 1.09-1.64).<br />Conclusions: Long-term fluctuations in metabolic syndrome parameters significantly increase the risk of total stroke, especially ischemic stroke. Maintaining low variability in metabolic syndrome parameters could benefit health, and hypertensive individuals must be regularly monitored.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Male
Middle Aged
Prospective Studies
Risk Factors
Incidence
Risk Assessment
Aged
Time Factors
China epidemiology
Prognosis
Triglycerides blood
Waist Circumference
Cholesterol, HDL blood
Adult
Metabolic Syndrome epidemiology
Metabolic Syndrome diagnosis
Metabolic Syndrome blood
Hypertension epidemiology
Hypertension diagnosis
Hypertension physiopathology
Stroke epidemiology
Stroke diagnosis
Blood Glucose metabolism
Blood Pressure
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 38879482
- Full Text :
- https://doi.org/10.1186/s12933-024-02282-3