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Dissecting SOX2 expression and function reveals an association with multiple signaling pathways during embryonic development and in cancer progression.
- Source :
-
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2024 Sep; Vol. 1879 (5), pp. 189136. Date of Electronic Publication: 2024 Jun 15. - Publication Year :
- 2024
-
Abstract
- SRY (Sex Determining Region) box 2 (SOX2) is an essential transcription factor that plays crucial roles in activating genes involved in pre- and post-embryonic development, adult tissue homeostasis, and lineage specifications. SOX2 maintains the self-renewal property of stem cells and is involved in the generation of induced pluripotency stem cells. SOX2 protein contains a particular high-mobility group domain that enables SOX2 to achieve the capacity to participate in a broad variety of functions. The information about the involvement of SOX2 with gene regulatory elements, signaling networks, and microRNA is gradually emerging, and the higher expression of SOX2 is functionally relevant to various cancer types. SOX2 facilitates the oncogenic phenotype via cellular proliferation and enhancement of invasive tumor properties. Evidence are accumulating in favor of three dimensional (higher order) folding of chromatin and epigenetic control of the SOX2 gene by chromatin modifications, which implies that the expression level of SOX2 can be modulated by epigenetic regulatory mechanisms, specifically, via DNA methylation and histone H3 modification. In view of this, and to focus further insights into the roles SOX2 plays in physiological functions, involvement of SOX2 during development, precisely, the advances of our knowledge in pre- and post-embryonic development, and interactions of SOX2 in this scenario with various signaling pathways in tumor development and cancer progression, its potential as a therapeutic target against many cancers are summarized and discussed in this article.<br />Competing Interests: Declaration of competing interest The authors declared no conflict of interest.<br /> (Copyright © 2023. Published by Elsevier B.V.)
- Subjects :
- Humans
Animals
Disease Progression
Epigenesis, Genetic
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
SOXB1 Transcription Factors genetics
SOXB1 Transcription Factors metabolism
Neoplasms genetics
Neoplasms pathology
Neoplasms metabolism
Embryonic Development genetics
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1879-2561
- Volume :
- 1879
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta. Reviews on cancer
- Publication Type :
- Academic Journal
- Accession number :
- 38880162
- Full Text :
- https://doi.org/10.1016/j.bbcan.2024.189136