Back to Search Start Over

Escherichia coli infection induces ferroptosis in bovine mammary epithelial cells by activating the Wnt/β-catenin pathway-mediated mitophagy.

Authors :
Zhuang C
Liu Y
Barkema HW
Deng Z
Gao J
Kastelic JP
Han B
Zhang J
Source :
Mitochondrion [Mitochondrion] 2024 Sep; Vol. 78, pp. 101921. Date of Electronic Publication: 2024 Jun 15.
Publication Year :
2024

Abstract

Iron overload causes mitochondrial damage, and then activates mitophagy, which may directly trigger and amplify ferroptosis. Our objective was to investigate whether Escherichia coli (E. coli) isolated from clinical bovine mastitis induces ferroptosis in bovine mammary epithelial cells (bMECs) and if so, the underlying regulatory mechanism. E. coli infection caused mitochondrial damage, mitophagy, and ferroptosis. Rapamycin and chloroquine increased and suppressed ferroptosis, respectively, in E. coli-treated bMECs. Moreover, E. coli infection activated the Wnt/β-catenin pathway, but foscenvivint alleviated it. In conclusion, E. coli infection induced ferroptosis through activation of the Wnt/β-catenin pathway-promoted mitophagy, and it also suppressed GPX4 expression.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024. Published by Elsevier B.V.)

Details

Language :
English
ISSN :
1872-8278
Volume :
78
Database :
MEDLINE
Journal :
Mitochondrion
Publication Type :
Academic Journal
Accession number :
38885732
Full Text :
https://doi.org/10.1016/j.mito.2024.101921