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Poly(Lysine)-Derived Carbon Quantum Dots Conquer Enterococcus faecalis Biofilm-Induced Persistent Endodontic Infections.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2024 Jun 13; Vol. 19, pp. 5879-5893. Date of Electronic Publication: 2024 Jun 13 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Introduction: Persistent endodontic infections (PEIs) mediated by bacterial biofilm mainly cause persistent periapical inflammation, resulting in recurrent periapical abscesses and progressive bone destruction. However, conventional root canal disinfectants are highly damaging to the tooth and periodontal tissue and ineffective in treating persistent root canal infections. Antimicrobial materials that are biocompatible with apical tissues and can eliminate PEIs-associated bacteria are urgently needed.<br />Methods: Here, ε-poly (L-lysine) derived carbon quantum dots (PL-CQDs) are fabricated using pyrolysis to remove PEIs-associated bacterial biofilms.<br />Results: Due to their ultra-small size, high positive charge, and active reactive oxygen species (ROS) generation capacity, PL-CQDs exhibit highly effective antibacterial activity against Enterococcus faecalis ( E. faecalis ), which is greatly dependent on PL-CQDs concentrations. 100 µg/mL PL-CQDs could kill E. faecalis in 5 min. Importantly, PL-CQDs effectively achieved a reduction of biofilms in the isolated teeth model, disrupting the dense structure of biofilms. PL-CQDs have acceptable cytocompatibility and hemocompatibility in vitro and good biosafety in vivo.<br />Discussion: Thus, PL-CQDs provide a new strategy for treating E. faecalis -associated PEIs.<br />Competing Interests: The authors declare no competing financial interest.<br /> (© 2024 Xu et al.)
- Subjects :
- Animals
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Humans
Reactive Oxygen Species metabolism
Mice
Enterococcus faecalis drug effects
Enterococcus faecalis physiology
Quantum Dots chemistry
Biofilms drug effects
Polylysine chemistry
Polylysine pharmacology
Carbon chemistry
Carbon pharmacology
Gram-Positive Bacterial Infections drug therapy
Gram-Positive Bacterial Infections microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 19
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 38895145
- Full Text :
- https://doi.org/10.2147/IJN.S453385