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Childhood maltreatment and risk of metabolic dysfunction-associated steatotic liver disease - Evidence of sex-specific associations in the general population.
- Source :
-
Journal of psychosomatic research [J Psychosom Res] 2024 Aug; Vol. 183, pp. 111829. Date of Electronic Publication: 2024 Jun 10. - Publication Year :
- 2024
-
Abstract
- Background and Aims: Childhood maltreatment (CM) is linked to self-reported liver disease in adulthood. However, specific diagnostic entities, e.g., metabolic dysfunction-associated steatotic liver disease (MASLD) as the most frequent chronic liver disease, and sex-differences have previously not been considered.<br />Methods: Cross-sectional analyses were conducted in 4188 adults from a population-based cohort in Northeastern Germany after excluding individuals with excessive alcohol consumption, cirrhosis, or chronic viral hepatitis. CM-exposure was assessed using the Childhood Trauma Questionnaire (CTQ). Liver-related outcomes included serologic liver enzymes, fibrosis-4 score (FIB-4) and, in 1863 subjects who underwent magnetic resonance imaging examination, liver fat content. Sex-stratified linear regression and logistic regression models predicting liver-related outcomes and risk for MASLD, respectively, from overall CTQ scores were adjusted for age, school education, alcohol consumption, and waist circumference. Exploratory analyses investigated effects of CTQ-subscales on liver-related outcomes and risk for MASLD.<br />Results: In both sexes, overall CM-exposure was associated with higher levels of serum aspartate aminotransferase and FIB-4 score. In men, effects were mainly driven by physical abuse, and in women by emotional neglect. Only in men, overall CM-exposure (β = 0.70, 95%-CI 0.26-1.13, p = 0.002) and four CTQ-subscales were associated with greater liver fat content, and physical abuse (aOR = 1.22, 95%-CI 1.02-1.46, p = 0.034) and physical neglect (aOR = 1.25, 95%-CI 1.04-1.49, p = 0.015) were associated with higher risk for MASLD.<br />Conclusions: These results suggest sex differences in the association between CM and objective serum and imaging markers of MASLD in adulthood. For men especially, a history of CM-exposure may increase risk of developing MASLD in adulthood.<br />Competing Interests: Declaration of competing interest The authors have no competing interests to declare.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Cross-Sectional Studies
Middle Aged
Adult
Germany epidemiology
Sex Factors
Child Abuse statistics & numerical data
Child Abuse psychology
Adverse Childhood Experiences statistics & numerical data
Adult Survivors of Child Abuse statistics & numerical data
Risk Factors
Aged
Fatty Liver
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1360
- Volume :
- 183
- Database :
- MEDLINE
- Journal :
- Journal of psychosomatic research
- Publication Type :
- Academic Journal
- Accession number :
- 38896985
- Full Text :
- https://doi.org/10.1016/j.jpsychores.2024.111829