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In situ comparison of osteogenic effects of polymer-based scaffolds with different degradability by integrated scaffold model.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Sep; Vol. 241, pp. 114047. Date of Electronic Publication: 2024 Jun 17. - Publication Year :
- 2024
-
Abstract
- Polymer-based scaffolds with different degradability have been investigated to screen the matrix whose degradation rate is more closely matched with the bone regeneration rate. However, these comparisons are inclined to be compromised by the animal individual differences. In this study, we constructed an integrated scaffold model comprising four parts with different degradability and bioactivity to achieve an in situ comparison of bone regeneration ability of different scaffolds. Slow-degradable polycaprolactone (PCL), fast-degradable poly (lactic-co-glycolic acid) (PLGA), and silica-coated PCL and PLGA scaffolds were assembled into a round sheet to form a hydroxyapatite (HA)-free integrated scaffold. HA-doped PCL, PLGA, and silica-coated PCL and PLGA scaffolds were assembled to create an HA-incorporated integrated scaffold. The in vivo experimental results demonstrated that the local acid microenvironment caused by the rapid degradation of PLGA interfered with the osteogenic process promoted by PCL-based scaffolds in defect areas implanted with HA-free integrated scaffolds. Since the incorporation of HA alleviated the acidic microenvironment to some extent, each scaffold in HA-incorporated scaffolds exhibited its expected bone regeneration capacity. Consequently, it is feasible to construct an integrated structure for comparing the osteogenic effects of various scaffolds in situ, when there is no mutual interference between the materials. The strategy presented in this study inspired the structure design of biomaterials to enable in situ comparison of bone regeneration capacity of scaffolds.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Bone Regeneration drug effects
Polymers chemistry
Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Polyglycolic Acid chemistry
Tissue Engineering methods
Lactic Acid chemistry
Tissue Scaffolds chemistry
Osteogenesis drug effects
Polylactic Acid-Polyglycolic Acid Copolymer chemistry
Polyesters chemistry
Durapatite chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 241
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 38897025
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2024.114047