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γ-Cyclodextrin hydrogel for the sustained release of josamycin for potential ocular application.
- Source :
-
Drug delivery [Drug Deliv] 2024 Dec; Vol. 31 (1), pp. 2361168. Date of Electronic Publication: 2024 Jun 20. - Publication Year :
- 2024
-
Abstract
- Glaucoma is the leading cause of blindness worldwide. However, its surgical treatment, in particular via trabeculectomy, can be complicated by fibrosis. In current clinical practice, application of the drug, Mitomycin C, prevents or delays fibrosis, but can lead to additional side effects, such as bleb leakage and hypotony. Previous in silico drug screening and in vitro testing has identified the known antibiotic, josamycin, as a possible alternative antifibrotic medication with potentially fewer side effects. However, a suitable ocular delivery mechanism for the hydrophobic drug to the surgical site does not yet exist. Therefore, the focus of this paper is the development of an implantable drug delivery system for sustained delivery of josamycin after glaucoma surgery based on crosslinked γ-cyclodextrin. γ-Cyclodextrin is a commonly used solubilizer which was shown to complex with josamycin, drastically increasing the drug's solubility in aqueous solutions. A simple γ-cyclodextrin crosslinking method produced biocompatible hydrogels well-suited for implantation. The crosslinked γ - cyclodextrin retained the ability to form complexes with josamycin, resulting in a 4-fold higher drug loading efficiency when compared to linear dextran hydrogels, and prolonged drug release over 4 days.
- Subjects :
- Drug Liberation
Drug Delivery Systems methods
Glaucoma drug therapy
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Drug Carriers chemistry
Animals
Humans
Cross-Linking Reagents chemistry
Hydrogels chemistry
Delayed-Action Preparations
gamma-Cyclodextrins chemistry
Solubility
Subjects
Details
- Language :
- English
- ISSN :
- 1521-0464
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Drug delivery
- Publication Type :
- Academic Journal
- Accession number :
- 38899440
- Full Text :
- https://doi.org/10.1080/10717544.2024.2361168