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Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2024 Jun; Vol. 47 (6), pp. 538-557. Date of Electronic Publication: 2024 Jun 20. - Publication Year :
- 2024
-
Abstract
- Age-related macular degeneration (AMD) is the leading cause of vision loss in senior adults. The disease can be categorized into two types: wet AMD and dry AMD. Wet AMD, also known as exudative or neovascular AMD, is less common but more severe than dry AMD and is responsible for 90% of the visual impairment caused by AMD and affects 20 million people worldwide. Current treatment options mainly involve biologics that inhibit the vascular endothelial growth factor or complement pathways. However, these treatments have limitations such as high cost, injection-related risks, and limited efficacy. Therefore, new therapeutic targets and strategies have been explored to improve the outcomes of patients with AMD. A promising approach is the use of small-molecule drugs that modulate different factors involved in AMD pathogenesis, such as tyrosine kinases and integrins. Small-molecule drugs offer advantages, such as oral administration, low cost, good penetration, and increased specificity for the treatment of wet and dry AMD. This review summarizes the current status and prospects of small-molecule drugs for the treatment of wet AMD. These advances are expected to support the development of effective and targeted treatments for patients with AMD.<br /> (© 2024. The Pharmaceutical Society of Korea.)
- Subjects :
- Humans
Small Molecule Libraries pharmacology
Animals
Angiogenesis Inhibitors therapeutic use
Angiogenesis Inhibitors pharmacology
Angiogenesis Inhibitors administration & dosage
Wet Macular Degeneration drug therapy
Drug Development methods
Vascular Endothelial Growth Factor A antagonists & inhibitors
Vascular Endothelial Growth Factor A metabolism
Macular Degeneration drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1976-3786
- Volume :
- 47
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 38902481
- Full Text :
- https://doi.org/10.1007/s12272-024-01503-3