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Glutamine Protects against Mouse Abdominal Aortic Aneurysm through Modulating VSMC Apoptosis and M1 Macrophage Activation.
- Source :
-
International journal of medical sciences [Int J Med Sci] 2024 May 19; Vol. 21 (8), pp. 1414-1427. Date of Electronic Publication: 2024 May 19 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Glutamine (Gln), known as the most abundant free amino acid, is widely spread in human body. In this study, we demonstrated the protective effects of glutamine against mouse abdominal aortic aneurysm (AAA) induced by both angiotensin II (AngII) and calcium phosphate (Ca <subscript>3</subscript> (PO <subscript>4</subscript> ) <subscript>2</subscript> ) in vivo , which was characterized with lower incidence of mouse AAA. Moreover, histomorphological staining visually presented more intact elastic fiber and less collagen deposition in abdominal aortas of mice treated by glutamine. Further, we found glutamine inhibited the excessive production of reactive oxide species (ROS), activity of matrix metalloproteinase (MMP), M1 macrophage activation, and apoptosis of vascular smooth muscle cells (VSMCs) in suprarenal abdominal aortas of mice, what's more, the high expressions of MMP-2 protein, MMP-9 protein, pro-apoptotic proteins, and IL-6 as well as TNF-α in protein and mRNA levels in cells treated by AngII were down-regulated by glutamine. Collectively, these results revealed that glutamine protected against mouse AAA through inhibiting apoptosis of VSMCs, M1 macrophage activation, oxidative stress, and extracellular matrix degradation.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)
- Subjects :
- Animals
Mice
Humans
Reactive Oxygen Species metabolism
Disease Models, Animal
Male
Macrophages drug effects
Macrophages metabolism
Macrophages immunology
Aorta, Abdominal pathology
Aorta, Abdominal drug effects
Matrix Metalloproteinase 9 metabolism
Matrix Metalloproteinase 2 metabolism
Tumor Necrosis Factor-alpha metabolism
Interleukin-6 metabolism
Calcium Phosphates
Aortic Aneurysm, Abdominal pathology
Aortic Aneurysm, Abdominal prevention & control
Aortic Aneurysm, Abdominal metabolism
Apoptosis drug effects
Glutamine pharmacology
Angiotensin II pharmacology
Macrophage Activation drug effects
Muscle, Smooth, Vascular drug effects
Muscle, Smooth, Vascular pathology
Muscle, Smooth, Vascular cytology
Myocytes, Smooth Muscle drug effects
Myocytes, Smooth Muscle metabolism
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1449-1907
- Volume :
- 21
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38903916
- Full Text :
- https://doi.org/10.7150/ijms.96395