Back to Search Start Over

CD147 regulates the formation and function of immune synapses.

Authors :
Xu Y
Zhang K
Miao J
Guo N
Fu X
Yang F
Luo X
Jia J
Zheng Z
Zhu P
Source :
Cellular immunology [Cell Immunol] 2024 Jul-Aug; Vol. 401-402, pp. 104845. Date of Electronic Publication: 2024 Jun 19.
Publication Year :
2024

Abstract

CD147 is a T cell activation-associated molecule which is closely involved in the formation of the immune synapse (IS). However, the precise role of CD147 in T cell activation and IS formation remains unclear. In the present study, we demonstrated that CD147 translocated to the IS upon T cell activation and was primarily distributed in the peripheral super molecular cluster (p-SMAC). The knock down of CD147 expression in T cells, but not in B cells, impaired IS formation. CD147 participated in IS formation between T cells and different types of antigen-presenting cells (APCs), including macrophages and dendritic cells. Ligation of CD147 with its monoclonal antibody (mAb) HAb18 effectively inhibited T cell activation and IL-2 secretion. CD98, a critical molecule interacting with CD147, was distributed in IS in a CD147-dependent way. Phosphorylation levels of T cell receptor (TCR) related molecules, like ZAP-70, ERK, and cJun, were down-regulated by CD147 ligation, which is crucial for the interaction of CD147 and TCR signaling transduction. CD147 is indispensable for the formation of immune synapses and plays an important role in the regulation of its function.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1090-2163
Volume :
401-402
Database :
MEDLINE
Journal :
Cellular immunology
Publication Type :
Academic Journal
Accession number :
38909549
Full Text :
https://doi.org/10.1016/j.cellimm.2024.104845