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Targeting CD300ld to normalize the tumor microenvironment: an emerging insight in cancer immunotherapy.
- Source :
-
MedComm [MedComm (2020)] 2024 Jun 20; Vol. 5 (7), pp. e607. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- In a recent Nature elegant study, Wang et al. identified CD300ld, a novel functionally highly conserved tumor immunosuppressive receptor, highly expressed specifically on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), as well as a key receptor in the regulation of recruitment and immunosuppressive function of PMN-MDSCs. Targeting CD300ld could remodel the tumor immune microenvironment, resulting in a broad-spectrum anti-tumor effect.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.)
Details
- Language :
- English
- ISSN :
- 2688-2663
- Volume :
- 5
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- MedComm
- Publication Type :
- Academic Journal
- Accession number :
- 38911066
- Full Text :
- https://doi.org/10.1002/mco2.607