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Associations of air pollution with acute coronary syndromes based on A/B/AB versus O blood types: case-crossover study.
- Source :
-
Scientific reports [Sci Rep] 2024 Jun 25; Vol. 14 (1), pp. 14580. Date of Electronic Publication: 2024 Jun 25. - Publication Year :
- 2024
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Abstract
- Short-term exposure to air pollutants may contribute to an increased risk of acute coronary syndrome (ACS). This study assessed the role of short-term exposure to fine particulate matter (PM <subscript>2.5</subscript> ) as well as fine and coarse PM (PM <subscript>10</subscript> ) air pollution in ACS events and the effect of blood groups on this phenomenon. A retrospectively collected database of 9026 patients was evaluated. The study design was a case-crossover using a conditional logistic regression model. The main analysis focused on PM <subscript>2.5</subscript> levels with a 1 day lag until the ACS event, using threshold-modelled predictor for all patients. Secondary analyses utilized separate threshold-modelled predictors for 2-7-days moving averages and for patients from specific ABO blood groups. Additional analysis was performed with the non-threshold models and for PM <subscript>10</subscript> levels. Short-term exposure to increased PM <subscript>2.5</subscript> and PM <subscript>10</subscript> levels at a 1-day lag was associated with elevated risks of ACS (PM <subscript>2.5</subscript> : OR = 1.012 per + 10 µg/m <superscript>3</superscript> , 95% CI 1.003, 1.021; PM <subscript>10</subscript> : OR = 1.014 per + 10 µg/m <superscript>3</superscript> , CI 1.002, 1.025) for all patients. Analysis showed that exposure to PM <subscript>2.5</subscript> was associated with increased risk of ACS at a 1-day lag for the A, B or AB group (OR = 1.012 per + 10 µg/m <superscript>3</superscript> , CI 1.001, 1.024), but not O group (OR = 1.011 per + 10 µg/m <superscript>3</superscript> , CI 0.994, 1.029). Additional analysis showed positive associations between exposure to PM <subscript>10</subscript> and risk of ACS, with 7-days moving average models stratified by blood group revealing that exposures to PM <subscript>2.5</subscript> and PM <subscript>10</subscript> were associated with elevated risk of ACS for patients with group O. Short-term exposures to PM <subscript>2.5</subscript> and PM <subscript>10</subscript> were associated with elevated risk of ACS. Short-term exposure to PM <subscript>2.5</subscript> was positively associated with the risk of ACS for patients with A, B, or AB blood groups for a 1-day lag, while risk in O group was delayed to 7 days.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Aged
Retrospective Studies
Air Pollutants adverse effects
ABO Blood-Group System
Environmental Exposure adverse effects
Risk Factors
Acute Coronary Syndrome blood
Acute Coronary Syndrome etiology
Acute Coronary Syndrome epidemiology
Particulate Matter adverse effects
Air Pollution adverse effects
Cross-Over Studies
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38918482
- Full Text :
- https://doi.org/10.1038/s41598-024-65506-2