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Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751.
- Source :
-
Marine drugs [Mar Drugs] 2024 Jun 03; Vol. 22 (6). Date of Electronic Publication: 2024 Jun 03. - Publication Year :
- 2024
-
Abstract
- A new dimeric C-glycoside polyketide chrysomycin F ( 1 ), along with four new monomeric compounds, chrysomycins G ( 2 ), H ( 3 ), I ( 4 ), J ( 5 ), as well as three known analogues, chrysomycins A ( 6 ), B ( 7 ), and C ( 8 ), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains.
- Subjects :
- Glycosides chemistry
Glycosides pharmacology
Glycosides isolation & purification
China
Molecular Structure
Anthraquinones pharmacology
Anthraquinones chemistry
Anthraquinones isolation & purification
Streptomyces chemistry
Streptomyces metabolism
Mycobacterium tuberculosis drug effects
Antitubercular Agents pharmacology
Antitubercular Agents chemistry
Antitubercular Agents isolation & purification
Polyketides pharmacology
Polyketides chemistry
Polyketides isolation & purification
Microbial Sensitivity Tests
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 38921570
- Full Text :
- https://doi.org/10.3390/md22060259