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Concomitant Botulinum Toxin Injections for Neurogenic Detrusor Overactivity and Spasticity-A Retrospective Analysis of Practice and Safety.
- Source :
-
Toxins [Toxins (Basel)] 2024 May 28; Vol. 16 (6). Date of Electronic Publication: 2024 May 28. - Publication Year :
- 2024
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Abstract
- As multiple indications for botulinum toxin injections (BTIs) can coexist for neurological patients, there are to date no description of concomitant injections (CIs) to treat both spasticity and neurogenic detrusor overactivity incontinence (NDOI) in patients with spinal cord injuries (SCIs) and multiple sclerosis (MS). We therefore identified patients followed at our institution by health data hub digging, using a specific procedure coding system in use in France, who have been treated at least once with detrusor and skeletal muscle BTIs within the same 1-month period, over the past 5 years (2017-2021). We analyzed 72 patients representing 319 CIs. Fifty (69%) were male, and the patients were mostly SCI (76%) and MS (18%) patients and were treated by a mean number of CIs of 4.4 ± 3.6 [1-14]. The mean cumulative dose was 442.1 ± 98.8 U, and 95% of CIs were performed within a 72 h timeframe. Among all CIs, five patients had symptoms evocative of distant spread but only one had a confirmed pathological jitter in single-fiber EMG. Eleven discontinued CIs for surgical alternatives: enterocystoplasty (five), tenotomy (three), intrathecal baclofen (two) and neurotomy (one). Concomitant BTIs for treating both spasticity and NDOI at the same time appeared safe when performed within a short delay and in compliance with actual knowledge for maximum doses.
- Subjects :
- Humans
Male
Female
Retrospective Studies
Middle Aged
Adult
Multiple Sclerosis complications
Multiple Sclerosis drug therapy
Neuromuscular Agents administration & dosage
Neuromuscular Agents therapeutic use
Botulinum Toxins, Type A administration & dosage
Botulinum Toxins, Type A adverse effects
Botulinum Toxins, Type A therapeutic use
Urinary Bladder, Neurogenic drug therapy
Aged
Injections, Intramuscular
Treatment Outcome
Muscle Spasticity drug therapy
Urinary Bladder, Overactive drug therapy
Spinal Cord Injuries complications
Spinal Cord Injuries drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 38922146
- Full Text :
- https://doi.org/10.3390/toxins16060252