Back to Search Start Over

Anticancer immune reaction and lymph node sinus macrophages: a review from human and animal studies.

Authors :
Fujiwara Y
Yano H
Pan C
Shiota T
Komohara Y
Source :
Journal of clinical and experimental hematopathology : JCEH [J Clin Exp Hematop] 2024; Vol. 64 (2), pp. 71-78.
Publication Year :
2024

Abstract

Lymph nodes are secondary lymphoid organs localized throughout the body that typically appear as bean-like nodules. Numerous antigen-presenting cells, including dendritic cells and macrophages, that mediate host defense responses against pathogens, such as bacteria and viruses, reside within lymph nodes. To react to cancer cell-derived antigens in a variety of cancers, antigen-presenting cells induce cytotoxic T lymphocytes (CTLs). In relation to anticancer immune responses, macrophages in the lymph node sinus have been of particular interest because a number of studies involving both human specimens and animal models have reported that lymph node macrophages expressing CD169 play a key role in activating anticancer CTLs. Recent studies have indicated that dysfunction of lymph node macrophages potentially contributes to immune suppression in elderly patients and immunological "cold" tumors. Therefore, in anticancer therapy, the regulation of lymph node macrophages is a potentially promising approach.

Details

Language :
English
ISSN :
1880-9952
Volume :
64
Issue :
2
Database :
MEDLINE
Journal :
Journal of clinical and experimental hematopathology : JCEH
Publication Type :
Academic Journal
Accession number :
38925976
Full Text :
https://doi.org/10.3960/jslrt.24017