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SARS-CoV-2 vaccination in inflammatory bowel disease (IBD) patients - does treatment for IBD negatively affect SARS-CoV-2 antibodies? A single-centre, prospective study.
- Source :
-
Przeglad gastroenterologiczny [Prz Gastroenterol] 2024; Vol. 19 (2), pp. 198-205. Date of Electronic Publication: 2023 Jul 27. - Publication Year :
- 2024
-
Abstract
- Introduction: Inflammatory bowel disease (IBD) patients use a wide variety of immunosuppressive drugs, including biologics, but their effect on SARS-CoV-2 vaccine antibody levels remains a mystery.<br />Aim: We analysed whether the drugs used in the treatment of IBD patients could affect the concentration of SARS-CoV-2 antibodies.<br />Material and Methods: This is a prospective, single-centre evaluation of the persistence of SARS-CoV-2 antibodies after vaccination at various time points: every 2 months throughout the 6 <superscript>th</superscript> month after the first dose.<br />Results: We included a total of 346 vaccinated IBD patients in the study. A negative correlation between antibody level and time from full vaccination was confirmed for the following types of therapy: infliximab (rho = -0.32, p < 0.001), adalimumab (rho = -0.35, p = 0.025), and vedolizumab (rho = -0.50, p < 0.001). In the case of other, long-term drug administration, a negative correlation between antibody level and time from full vaccination was confirmed for mesalazine (rho = -0.35, p < 0.001), budesonide (rho = -0.58, p = 0.004), systemic glucocorticoids (rho = -0.58, p < 0.001), and azathioprine (rho = -0.44, p < 0.001).<br />Conclusions: Due to the immunosuppressive and biological treatment, IBD patients are exposed to a shorter persistence of SARS-CoV-2 antibodies and require booster doses. The role of gastroenterologists in educating patients about the need to continue SARS-CoV-2 vaccination remains crucial.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2024 Termedia.)
Details
- Language :
- English
- ISSN :
- 1895-5770
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Przeglad gastroenterologiczny
- Publication Type :
- Academic Journal
- Accession number :
- 38939061
- Full Text :
- https://doi.org/10.5114/pg.2023.130126