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Lactobacillus rhamnosus GG alleviates radiation-induced intestinal injury by modulating intestinal immunity and remodeling gut microbiota.

Authors :
Zhang LL
Xu JY
Xing Y
Wu P
Jin YW
Wei W
Zhao L
Yang J
Chen GC
Qin LQ
Source :
Microbiological research [Microbiol Res] 2024 Sep; Vol. 286, pp. 127821. Date of Electronic Publication: 2024 Jun 25.
Publication Year :
2024

Abstract

Radiation injury to the intestine is one of the most common complications in patients undergoing abdominal or pelvic cavity radiotherapy. In this study, we investigated the potential protective effect of Lactobacillus rhamnosus GG (LGG) on radiation-induced intestinal injury and its underlying mechanisms. Mice were assigned to a control group, a 10 Gy total abdominal irradiation (TAI) group, or a group pretreated with 10 <superscript>8</superscript> CFU LGG for three days before TAI. Small intestine and gut microbiota were analyzed 3.5 days post-exposure. LGG intervention improved intestinal structure, reduced jejunal DNA damage, and inhibited the inflammatory cGAS/STING pathway. Furthermore, LGG reduced M1 proinflammatory macrophage and CD8+ T cell infiltration, restoring the balance between Th17 and Treg cells in the inflamed jejunum. LGG also partially restored the gut microbiota. These findings suggest the possible therapeutic radioprotective effect of probiotics LGG in alleviating radiation-induced intestinal injury by maintaining immune homeostasis and reshaping gut microbiota.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier GmbH. All rights reserved.)

Details

Language :
English
ISSN :
1618-0623
Volume :
286
Database :
MEDLINE
Journal :
Microbiological research
Publication Type :
Academic Journal
Accession number :
38941923
Full Text :
https://doi.org/10.1016/j.micres.2024.127821