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Characterization of proinflammatory cytokines profile during acute SARS-CoV-2 infection in people with human immunodeficiency virus.
- Source :
-
Japanese journal of infectious diseases [Jpn J Infect Dis] 2024 Jun 28. Date of Electronic Publication: 2024 Jun 28. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Persistent inflammation in chronic HIV infection may affect immune responses against SARS-CoV-2 infection. Plasma levels of multiple proinflammatory cytokines during acute SARS-CoV-2 infection were assessed in people with HIV (PWH) with effective cART. There were no significant differences in any of the tested cytokines between COVID-19 severity in PWH, while most of them were significantly higher in individuals with severe disease in HIV-uninfected individuals, suggesting that excess cytokines release by hyper-inflammatory responses does not occur in severe COVID-19 with HIV infection. The strong associations between the cytokines observed in HIV-uninfected individuals, especially between IFN-α/TNF-α and other cytokines, were lost in PWH. The steady state plasma levels of IP-10, ICAM-1, and CD62E were significantly higher in PWH, indicating that PWH are in an enhanced inflammatory state. Loss of the several inter-cytokine correlations were observed in in vitro LPS stimuli-driven cytokines production in PWH. These data suggest that inflammatory responses during SARS-CoV-2 infection in PWH are distinct from those in HIV-uninfected individuals, partially due to the underlying inflammatory state and/or impairment of innate immune cells.
Details
- Language :
- English
- ISSN :
- 1884-2836
- Database :
- MEDLINE
- Journal :
- Japanese journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 38945856
- Full Text :
- https://doi.org/10.7883/yoken.JJID.2024.184