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Three Undescribed Protoilludane-Type Sesquiterpene Aryl Esters from Armillaria gallica.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2024 Jul 01, pp. e202401303. Date of Electronic Publication: 2024 Jul 01. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Three previously undescribed protoilludane-type sesquiterpene aryl esters, armillanals A-C (1-3), along with seven known ones (4-10) were obtained from Armillaria gallica Marxm. & Romagn. Compounds 1 and 2 were a rare class of sesquiterpenes featuring the Δ <superscript>2(3)</superscript> and Δ <superscript>12(13)</superscript> -protoilludane skeleton. Their structures were established by extensive spectroscopic methods. Based on electronic circular dichroism (ECD) calculations, the absolute configurations of three new compounds (1-3) were determined. The anti-inflammatory activity of compounds 1-10 was screened and compound 3 could dose-dependently decrease the level of lactate dehydrogenase, showing IC <subscript>50</subscript> value of 4.525 μM.<br /> (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Details
- Language :
- English
- ISSN :
- 1612-1880
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 38946608
- Full Text :
- https://doi.org/10.1002/cbdv.202401303