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STAT3 gain of function: Too much of a good thing in the skin!
- Source :
-
The Journal of experimental medicine [J Exp Med] 2024 Aug 05; Vol. 221 (8). Date of Electronic Publication: 2024 Jul 01. - Publication Year :
- 2024
-
Abstract
- Germline activating mutations in STAT3 cause a multi-systemic autoimmune and autoinflammatory condition. By studying a mouse model, Toth et al. (https://doi.org/10.1084/jem.20232091) propose a role for dysregulated IL-22 production by Th17 cells in causing some aspects of immune-mediated skin inflammation in human STAT3 GOF syndrome.<br /> (© 2024 Ma and Tangye.)
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 221
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38949650
- Full Text :
- https://doi.org/10.1084/jem.20240849