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Antitumor activity of anlotinib in malignant melanoma: modulation of angiogenesis and vasculogenic mimicry.
- Source :
-
Archives of dermatological research [Arch Dermatol Res] 2024 Jul 03; Vol. 316 (7), pp. 447. Date of Electronic Publication: 2024 Jul 03. - Publication Year :
- 2024
-
Abstract
- Malignant melanoma presents a formidable challenge due to its aggressive metastatic behavior and limited response to current treatments. To address this, our study delves into the impact of anlotinib on angiogenesis and vasculogenic mimicry using malignant melanoma cells and human umbilical vein endothelial cells. Evaluating tubular structure formation, cell proliferation, migration, invasion, and key signaling molecules in angiogenesis, we demonstrated that anlotinib exerts a dose-dependent inhibition on tubular structures and effectively suppresses cell growth and invasion in both cell types. Furthermore, in a mouse xenograft model, anlotinib treatment resulted in reduced tumor growth and vascular density. Notably, the downregulation of VEGFR-2, FGFR-1, PDGFR-β, and PI3K underscored the multitargeted antitumor activity of anlotinib. Our findings emphasize the therapeutic potential of anlotinib in targeting angiogenesis and vasculogenic mimicry, contributing to the development of novel strategies for combating malignant melanoma.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Humans
Animals
Mice
Cell Line, Tumor
Receptor, Fibroblast Growth Factor, Type 1 metabolism
Receptor, Fibroblast Growth Factor, Type 1 antagonists & inhibitors
Skin Neoplasms drug therapy
Skin Neoplasms pathology
Signal Transduction drug effects
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Angiogenesis Inhibitors pharmacology
Angiogenesis Inhibitors administration & dosage
Angiogenesis Inhibitors therapeutic use
Receptor, Platelet-Derived Growth Factor beta metabolism
Receptor, Platelet-Derived Growth Factor beta antagonists & inhibitors
Mice, Nude
Angiogenesis
Quinolines pharmacology
Quinolines therapeutic use
Quinolines administration & dosage
Melanoma drug therapy
Melanoma pathology
Neovascularization, Pathologic drug therapy
Neovascularization, Pathologic pathology
Indoles pharmacology
Indoles therapeutic use
Xenograft Model Antitumor Assays
Cell Proliferation drug effects
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor Receptor-2 metabolism
Vascular Endothelial Growth Factor Receptor-2 antagonists & inhibitors
Cell Movement drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1432-069X
- Volume :
- 316
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Archives of dermatological research
- Publication Type :
- Academic Journal
- Accession number :
- 38958761
- Full Text :
- https://doi.org/10.1007/s00403-024-03020-1