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Absorption enhancement of peach kernel oil on hydroxysafflor yellow A in safflower extracts and its mechanisms.
- Source :
-
Food chemistry [Food Chem] 2024 Nov 15; Vol. 458, pp. 140218. Date of Electronic Publication: 2024 Jun 25. - Publication Year :
- 2024
-
Abstract
- Carthamus tinctorius L. (Safflower) is extensively used as a functional food and herbal medicine, with its application closely associated with hydroxysafflor yellow A (HSYA). However, the low oral bioavailability of HSYA in safflower extract (SFE) limits its health benefits and application. Our study found that co-administration of 250, 330, and 400 mg/kg peach kernel oil (PKO) increased the oral bioavailability of HSYA in SFE by 1.99-, 2.11-, and 2.49-fold, respectively. The enhanced bioavailability is attributed to improved lipid solubility and intestinal permeability of HSYA in SFE due to PKO. PKO is believed to modify membrane fluidity and tight junctions, increase paracellular penetration, and inhibit the expression and function of P-glycoprotein, enhancing the transcellular transport of substrates. These mechanisms suggest that PKO is an effective absorption enhancer. Our findings provide valuable insights for developing functional foods with improved bioavailability.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Humans
Plant Oils chemistry
Male
Rats, Sprague-Dawley
Rats
Intestinal Absorption drug effects
Chalcone chemistry
Chalcone analogs & derivatives
Chalcone pharmacology
Plant Extracts chemistry
Plant Extracts administration & dosage
Plant Extracts metabolism
Quinones chemistry
Quinones metabolism
Carthamus tinctorius chemistry
Biological Availability
Prunus persica chemistry
Prunus persica metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7072
- Volume :
- 458
- Database :
- MEDLINE
- Journal :
- Food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38964104
- Full Text :
- https://doi.org/10.1016/j.foodchem.2024.140218