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Alterations of Placental Sodium in Preeclampsia: Trophoblast Responses.
- Source :
-
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Sep; Vol. 81 (9), pp. 1924-1934. Date of Electronic Publication: 2024 Jul 05. - Publication Year :
- 2024
-
Abstract
- Background: Evidence suggests that increasing salt intake in pregnancy lowers blood pressure, protecting against preeclampsia. We hypothesized that sodium (Na <superscript>+</superscript> ) evokes beneficial placental signals that are disrupted in preeclampsia.<br />Methods: Blood and urine were collected from nonpregnant women of reproductive age (n=26) and pregnant women with (n=50) and without (n=55) preeclampsia, along with placental biopsies. Human trophoblast cell lines and primary human trophoblasts were cultured with varying Na <superscript>+</superscript> concentrations.<br />Results: Women with preeclampsia had reduced placental and urinary Na <superscript>+</superscript> concentrations, yet increased urinary angiotensinogen and reduced active renin, aldosterone concentrations, and osmotic response signal TonEBP (tonicity-responsive enhancer binding protein) expression. In trophoblast cell cultures, TonEBP was consistently increased upon augmented Na <superscript>+</superscript> exposure. Mechanistically, inhibiting Na <superscript>+</superscript> /K <superscript>+</superscript> -ATPase or adding mannitol evoked the TonEBP response, whereas inhibition of cytoskeletal signaling abolished it.<br />Conclusions: Enhanced Na <superscript>+</superscript> availability induced osmotic gradient-dependent cytoskeletal signals in trophoblasts, resulting in proangiogenic responses. As placental salt availability is compromised in preeclampsia, adverse systemic responses are thus conceivable.<br />Competing Interests: None.
- Subjects :
- Humans
Female
Pregnancy
Adult
Aldosterone metabolism
Angiotensinogen metabolism
Cells, Cultured
Sodium-Potassium-Exchanging ATPase metabolism
Blood Pressure physiology
Blood Pressure drug effects
Renin metabolism
Transcription Factors
Pre-Eclampsia metabolism
Pre-Eclampsia physiopathology
Trophoblasts metabolism
Trophoblasts drug effects
Placenta metabolism
Placenta drug effects
Sodium metabolism
Sodium urine
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4563
- Volume :
- 81
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Publication Type :
- Academic Journal
- Accession number :
- 38966986
- Full Text :
- https://doi.org/10.1161/HYPERTENSIONAHA.124.23001