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Post-Coronavirus Disease-2019 Rhino-orbital Mucormycosis: A Case Report.
- Source :
-
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH [Nepal J Ophthalmol] 2023 Jul; Vol. 15 (30), pp. 108-115. - Publication Year :
- 2023
-
Abstract
- Background: Rhino-orbital-cerebral mucormycosis (ROCM) is a rare, opportunistic, angio-invasive, and fatal infection caused by mold fungi of the genera Rhizopus, Mucor, and Rhizomucor. The global incidence of ROCM is 0.005-1.7 per million, with a fatality rate of 46%. Early diagnosis and treatment are crucial for this disease, as a delay of one week can increase the mortality rate to 66%.<br />Case: A 32-year-old male, a known case of coronavirus disease 2019 (COVID-19) for the past 15 days from Janakpur, Dhanusha, Nepal presented to the emergency department of Dhulikhel Hospital with a sudden onset of blurred vision in the left eye, left-sided ocular pain, and nasal bleeding for the last three days.<br />Observations: The patient was suspected of post-COVID-19 mucormycosis, and a nasal swab for potassium hydroxide (KOH) mount showed hyphae in microscopy. Intravenous and retrobulbar liposomal amphotericin B were administered as medical therapy, along with surgical debridement. A multidisciplinary approach was necessary for the treatment.<br />Conclusion: A long-term, multimodal treatment approach involving combined antifungal drug therapy (intravenous liposomal amphotericin B and retrobulbar amphotericin B), and timely surgical debridement leads to an improvement in both short-term and long-term outcomes.<br /> (© NEPjOPH.)
- Subjects :
- Humans
Male
Adult
Amphotericin B therapeutic use
Nepal
Nose Diseases microbiology
Nose Diseases diagnosis
Nose Diseases therapy
Mucormycosis diagnosis
Mucormycosis therapy
COVID-19 complications
COVID-19 diagnosis
Eye Infections, Fungal diagnosis
Eye Infections, Fungal microbiology
Eye Infections, Fungal therapy
Eye Infections, Fungal drug therapy
Antifungal Agents therapeutic use
SARS-CoV-2
Orbital Diseases diagnosis
Orbital Diseases microbiology
Orbital Diseases therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2091-0320
- Volume :
- 15
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
- Publication Type :
- Academic Journal
- Accession number :
- 38976344
- Full Text :
- https://doi.org/10.3126/nepjoph.v15i2.46954