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Microglia are dispensable for experience-dependent refinement of mouse visual circuitry.
- Source :
-
Nature neuroscience [Nat Neurosci] 2024 Aug; Vol. 27 (8), pp. 1462-1467. Date of Electronic Publication: 2024 Jul 08. - Publication Year :
- 2024
-
Abstract
- To test the hypothesized crucial role of microglia in the developmental refinement of neural circuitry, we depleted microglia from mice of both sexes with PLX5622 and examined the experience-dependent maturation of visual circuitry and function. We assessed retinal function, receptive field tuning of visual cortex neurons, acuity and experience-dependent plasticity. None of these measurements detectibly differed in the absence of microglia, challenging the role of microglia in sculpting neural circuits.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Details
- Language :
- English
- ISSN :
- 1546-1726
- Volume :
- 27
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 38977886
- Full Text :
- https://doi.org/10.1038/s41593-024-01706-3