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Multikingdom and functional gut microbiota markers for autism spectrum disorder.
- Source :
-
Nature microbiology [Nat Microbiol] 2024 Sep; Vol. 9 (9), pp. 2344-2355. Date of Electronic Publication: 2024 Jul 08. - Publication Year :
- 2024
-
Abstract
- Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial component of the microbiome. Whether gut archaea, fungi and viruses, or function of the gut microbiome, is altered in ASD is unclear. Here we performed metagenomic sequencing on faecal samples from 1,627 children (aged 1-13 years, 24.4% female) with or without ASD, with extensive phenotype data. Integrated analyses revealed that 14 archaea, 51 bacteria, 7 fungi, 18 viruses, 27 microbial genes and 12 metabolic pathways were altered in children with ASD. Machine learning using single-kingdom panels showed area under the curve (AUC) of 0.68 to 0.87 in differentiating children with ASD from those that are neurotypical. A panel of 31 multikingdom and functional markers showed a superior diagnostic accuracy with an AUC of 0.91, with comparable performance for males and females. Accuracy of the model was predominantly driven by the biosynthesis pathways of ubiquinol-7 or thiamine diphosphate, which were less abundant in children with ASD. Collectively, our findings highlight the potential application of multikingdom and functional gut microbiota markers as non-invasive diagnostic tools in ASD.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
- Subjects :
- Humans
Female
Male
Child
Child, Preschool
Adolescent
Infant
Metagenomics methods
Machine Learning
Archaea genetics
Archaea metabolism
Archaea classification
Archaea isolation & purification
Fungi genetics
Fungi classification
Fungi isolation & purification
Viruses genetics
Viruses isolation & purification
Viruses classification
Metagenome
Gastrointestinal Microbiome genetics
Autism Spectrum Disorder microbiology
Autism Spectrum Disorder diagnosis
Feces microbiology
Biomarkers analysis
Bacteria genetics
Bacteria classification
Bacteria isolation & purification
Bacteria metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2058-5276
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nature microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 38977906
- Full Text :
- https://doi.org/10.1038/s41564-024-01739-1