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Silver-enriched microdomain patterns as advanced bactericidal coatings for polymer-based medical devices.

Authors :
Pryjmaková J
Vokatá B
Šlouf M
Hubáček T
Martínez-García P
Rebollar E
Slepička P
Siegel J
Source :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Oct; Vol. 242, pp. 114067. Date of Electronic Publication: 2024 Jul 06.
Publication Year :
2024

Abstract

Today, it would be difficult for us to live a full life without polymers, especially in medicine, where its applicability is constantly expanding, giving satisfactory results without any harm effects on health. This study focused on the formation of hexagonal domains doped with AgNPs using a KrF excimer laser (λ=248 nm) on the polyetheretherketone (PEEK) surface that acts as an unfailing source of the antibacterial agent - silver. The hexagonal structure was formed with a grid placed in front of the incident laser beam. Surfaces with immobilized silver nanoparticles (AgNPs) were observed by AFM and SEM. Changes in surface chemistry were studied by XPS. To determine the concentration of released Ag <superscript>+</superscript> ions, ICP-MS analysis was used. The antibacterial tests proved the antibacterial efficacy of Ag-doped PEEK composites against Escherichia coli and Staphylococcus aureus as the most common pathogens. Because AgNPs are also known for their strong toxicity, we also included cytotoxicity tests in this study. The findings presented here contribute to the advancement of materials design in the biomedical field, offering a novel starting point for combating bacterial infections through the innovative integration of AgNPs into inert synthetic polymers.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1873-4367
Volume :
242
Database :
MEDLINE
Journal :
Colloids and surfaces. B, Biointerfaces
Publication Type :
Academic Journal
Accession number :
38981327
Full Text :
https://doi.org/10.1016/j.colsurfb.2024.114067