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Silver-enriched microdomain patterns as advanced bactericidal coatings for polymer-based medical devices.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Oct; Vol. 242, pp. 114067. Date of Electronic Publication: 2024 Jul 06. - Publication Year :
- 2024
-
Abstract
- Today, it would be difficult for us to live a full life without polymers, especially in medicine, where its applicability is constantly expanding, giving satisfactory results without any harm effects on health. This study focused on the formation of hexagonal domains doped with AgNPs using a KrF excimer laser (λ=248 nm) on the polyetheretherketone (PEEK) surface that acts as an unfailing source of the antibacterial agent - silver. The hexagonal structure was formed with a grid placed in front of the incident laser beam. Surfaces with immobilized silver nanoparticles (AgNPs) were observed by AFM and SEM. Changes in surface chemistry were studied by XPS. To determine the concentration of released Ag <superscript>+</superscript> ions, ICP-MS analysis was used. The antibacterial tests proved the antibacterial efficacy of Ag-doped PEEK composites against Escherichia coli and Staphylococcus aureus as the most common pathogens. Because AgNPs are also known for their strong toxicity, we also included cytotoxicity tests in this study. The findings presented here contribute to the advancement of materials design in the biomedical field, offering a novel starting point for combating bacterial infections through the innovative integration of AgNPs into inert synthetic polymers.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Surface Properties
Ketones chemistry
Ketones pharmacology
Coated Materials, Biocompatible chemistry
Coated Materials, Biocompatible pharmacology
Humans
Equipment and Supplies microbiology
Particle Size
Silver chemistry
Silver pharmacology
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Polymers chemistry
Polymers pharmacology
Escherichia coli drug effects
Staphylococcus aureus drug effects
Polyethylene Glycols chemistry
Polyethylene Glycols pharmacology
Benzophenones chemistry
Benzophenones pharmacology
Microbial Sensitivity Tests
Metal Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 242
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 38981327
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2024.114067