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A network meta-analysis of non-invasive brain stimulation interventions for autism spectrum disorder: Evidence from randomized controlled trials.
- Source :
-
Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2024 Sep; Vol. 164, pp. 105807. Date of Electronic Publication: 2024 Jul 07. - Publication Year :
- 2024
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Abstract
- The efficacy and acceptability of various non-invasive brain stimulation (NIBS) interventions for autism spectrum disorder remain unclear. We carried out a systematic review for randomized controlled trials (RCTs) regarding NIBS for reducing autistic symptoms (INPLASY202370003). Sixteen articles (N = 709) met the inclusion criteria for network meta-analysis. Effect sizes were reported as standardized mean differences (SMDs) or odds ratios with 95 % confidence intervals (CIs). Fourteen active NIBS interventions, including transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation, and transcranial pulse stimulation were analyzed. Only anodal tDCS over the left dorsolateral prefrontal cortex paired with cathodal tDCS over an extracephalic location (atDCS&#95;F3 + ctDCS&#95;E) significantly improved autistic symptoms compared to sham controls (SMD = - 1.40, 95 %CIs = - 2.67 to - 0.14). None of the NIBS interventions markedly improved social-communication symptoms or restricted/repetitive behaviors in autistic participants. Moreover, no active NIBS interventions exhibited significant dropout rate differences compared to sham controls, and no serious adverse events were reported for any intervention.<br />Competing Interests: Conflict of interest statement All authors declare no financial interests or potential conflicts of interest regarding the authorship and publication of this article.<br /> (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-7528
- Volume :
- 164
- Database :
- MEDLINE
- Journal :
- Neuroscience and biobehavioral reviews
- Publication Type :
- Academic Journal
- Accession number :
- 38981573
- Full Text :
- https://doi.org/10.1016/j.neubiorev.2024.105807