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Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia.
- Source :
-
World journal of psychiatry [World J Psychiatry] 2024 Jun 19; Vol. 14 (6), pp. 794-803. Date of Electronic Publication: 2024 Jun 19 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Background: Accumulating evidence suggests that the inflammatory cytokine interleukin-6 (IL-6) contributes to the pathophysiology of psychiatric disorders. However, there was no study concerning the relationship between IL-6 concentrations and clinical features in the chronic phase of early-onset schizophrenia (EOS).<br />Aim: To investigate the relationship between serum IL-6 concentration and the clinical features of EOS.<br />Methods: We measured serum IL-6 Levels from 74 patients with chronic schizophrenia, including 33 with age at onset < 21 years (EOS group) and 41 with onset ≥ 21 years in [adult-onset schizophrenia (AOS) group], and from 41 healthy controls. Symptom severities were evaluated using the Positive and Negative Syndrome Scale (PANSS).<br />Results: Serum IL-6 concentrations were higher in both EOS and AOS groups than healthy controls ( F = 22.32, P < 0.01), but did not differ significantly between EOS and AOS groups ( P > 0.05) after controlling for age, body mass index, and other covariates. Negative symptom scores were higher in the EOS group than the AOS group ( F = 6.199, P = 0.015). Serum IL-6 concentrations in the EOS group were negatively correlated with both total PANSS-negative symptom score ( r = -0.389, P = 0.032) and avolition/asociality subscore ( r = -0.387, P = 0.026).<br />Conclusion: Patients with EOS may have more severe negative symptoms than those with adult-onset schizophrenia during the chronic phase of the illness. IL-6 signaling may regulate negative symptoms and its avolition/asociality subsymptoms among the early-onset chronic schizophrenic patients.<br />Competing Interests: Conflict-of-interest statement: No conflict of interest was disclosed for each author.<br /> (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2220-3206
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- World journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 38984340
- Full Text :
- https://doi.org/10.5498/wjp.v14.i6.794