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Blood protein assessment of leading incident diseases and mortality in the UK Biobank.
- Source :
-
Nature aging [Nat Aging] 2024 Jul; Vol. 4 (7), pp. 939-948. Date of Electronic Publication: 2024 Jul 10. - Publication Year :
- 2024
-
Abstract
- The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age-related diseases and mortality in the UK Biobank (nā=ā47,600). We report 3,209 associations between 963 protein levels and 21 incident outcomes. Next, protein-based scores (ProteinScores) are developed using penalized Cox regression. When applied to test sets, six ProteinScores improve the area under the curve estimates for the 10-year onset of incident outcomes beyond age, sex and a comprehensive set of 24 lifestyle factors, clinically relevant biomarkers and physical measures. Furthermore, the ProteinScore for type 2 diabetes outperforms a polygenic risk score and HbA1c-a clinical marker used to monitor and diagnose type 2 diabetes. The performance of scores using metabolomic and proteomic features is also compared. These data characterize early proteomic contributions to major age-related diseases, demonstrating the value of the plasma proteome for risk stratification.<br /> (© 2024. The Author(s).)
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
Biomarkers blood
Diabetes Mellitus, Type 2 mortality
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 epidemiology
Diabetes Mellitus, Type 2 genetics
Incidence
Proteomics
UK Biobank
United Kingdom epidemiology
Blood Proteins metabolism
Blood Proteins genetics
Blood Proteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2662-8465
- Volume :
- 4
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature aging
- Publication Type :
- Academic Journal
- Accession number :
- 38987645
- Full Text :
- https://doi.org/10.1038/s43587-024-00655-7