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Association between triglyceride glucose-waist height ratio index and cardiovascular disease in middle-aged and older Chinese individuals: a nationwide cohort study.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Jul 11; Vol. 23 (1), pp. 247. Date of Electronic Publication: 2024 Jul 11. - Publication Year :
- 2024
-
Abstract
- Background: The triglyceride-glucose (TyG) index and its combination with obesity indicators can predict cardiovascular diseases (CVD). However, there is limited research on the relationship between changes in the triglyceride glucose-waist height ratio (TyG-WHtR) and CVD. Our study aims to investigate the relationship between the change in the TyG-WHtR and the risk of CVD.<br />Methods: Participants were from the China Health and Retirement Longitudinal Study (CHARLS). CVD was defined as self-reporting heart disease and stroke. Participants were divided into three groups based on changes in TyG-WHtR using K-means cluster analysis. Multivariable binary logistic regression analysis was used to examine the association between different groups (based on the change of TyG-WHtR) and CVD. A restricted cubic spline (RCS) regression model was used to explore the potential nonlinear association of the cumulative TyG-WHtR and CVD events.<br />Results: During follow-up between 2015 and 2020, 623 (18.8%) of 3312 participants developed CVD. After adjusting for various potential confounders, compared to the participants with consistently low and stable TyG-WHtR, the risk of CVD was significantly higher in participants with moderate and increasing TyG-WHtR (OR 1.28, 95%CI 1.01-1.63) and participants with high TyG-WHtR with a slowly increasing trend (OR 1.58, 95%CI 1.16-2.15). Higher levels of cumulative TyG-WHtR were independently associated with a higher risk of CVD events (per SD, OR 1.27, 95%CI 1.12-1.43).<br />Conclusions: For middle-aged and older adults, changes in the TyG-WHtR are independently associated with the risk of CVD. Maintaining a favorable TyG index, effective weight management, and a reasonable waist circumference contribute to preventing CVD.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Male
Middle Aged
China epidemiology
Aged
Risk Assessment
Longitudinal Studies
Waist-Height Ratio
Age Factors
Time Factors
Prognosis
Predictive Value of Tests
Risk Factors
Heart Disease Risk Factors
Incidence
East Asian People
Cardiovascular Diseases epidemiology
Cardiovascular Diseases diagnosis
Cardiovascular Diseases blood
Triglycerides blood
Blood Glucose metabolism
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 38992634
- Full Text :
- https://doi.org/10.1186/s12933-024-02336-6