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Self-reporting intracellular delivery agent for singlet oxygen.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Jul 30; Vol. 60 (62), pp. 8111-8114. Date of Electronic Publication: 2024 Jul 30. - Publication Year :
- 2024
-
Abstract
- 1,4-Dimethylphenazine endoperoxide releases singlet oxygen with a half-life of 89 hours at 37 °C. The thermal cycloreversion reaction is accompanied by a strong increase in the emission intensity with a peak at 490 nm, due to the formation of the phenazine core. The endoperoxide is effective against cancer cells in culture medium and tumor spheroids, with singlet oxygen-mediated cytotoxicity.
- Subjects :
- Humans
Cell Survival drug effects
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Photosensitizing Agents chemistry
Photosensitizing Agents pharmacology
Molecular Structure
Singlet Oxygen metabolism
Singlet Oxygen chemistry
Phenazines chemistry
Phenazines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 60
- Issue :
- 62
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 38994648
- Full Text :
- https://doi.org/10.1039/d4cc02209b