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Polygenic scores for psychiatric disorders associate with year of first bipolar disorder diagnosis: A register-based study between 1972 and 2016.
- Source :
-
Psychiatry research [Psychiatry Res] 2024 Sep; Vol. 339, pp. 116081. Date of Electronic Publication: 2024 Jul 07. - Publication Year :
- 2024
-
Abstract
- The diagnostic criteria of bipolar disorder (BD) have changed over time. To test if these changes are reflected in the polygenic profile in BD, we studied the association between first BD diagnosis year (during 1972-2016) and polygenic scores (PGS) for psychiatric disorders in BD patients (N = 3,818). We found significant associations between diagnosis year and PGS for BD, depression, and attention deficit hyperactivity disorder (ADHD). The PGS remained largely stable over time in BD type 1, while changes were observed in BD type 2. These findings bear significance not only for genetic research but also for clinical practise, as shifts in patient characteristics can influence treatment response.<br />Competing Interests: Declaration of competing interest ML declares that he has received lecture honoraria from Lundbeck pharmaceutical outside the scope of this work. EJ is currently employed at IQVIA, Mölndal, Sweden.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Humans
Male
Female
Adult
Middle Aged
Young Adult
Adolescent
Bipolar Disorder genetics
Bipolar Disorder diagnosis
Bipolar Disorder epidemiology
Multifactorial Inheritance genetics
Registries
Attention Deficit Disorder with Hyperactivity genetics
Attention Deficit Disorder with Hyperactivity diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7123
- Volume :
- 339
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 38996631
- Full Text :
- https://doi.org/10.1016/j.psychres.2024.116081