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Shikonin ameliorates depressive- and anxiogenic-like behaviors in rats via the suppression of inflammation in the hippocampus.
- Source :
-
Neuroscience letters [Neurosci Lett] 2024 Aug 10; Vol. 837, pp. 137893. Date of Electronic Publication: 2024 Jul 10. - Publication Year :
- 2024
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Abstract
- Shikonin is an active naphthoquinone with antioxidative, anti-inflammatory, and anticancer properties. In this study, we investigated the effects of shikonin on depressive- and anxiety-like behaviors in lipopolysaccharide- (LPS-) induced depression and chronic unpredictable mild stress (CUMS) rat models and explored the potential mechanism. First, a 14-day intraperitoneal administration of shikonin (10 mg/kg) significantly decreased immobility time in forced swimming test (FST) and increased open arm entries in elevated plus maze (EPM) test, without affecting line crossings in open field test (OFT), indicating that shikonin has anti-depressant- and anxiolytic-like effects. Second, chronic shikonin administration (10 mg/kg) reversed depressive- and anxiety-like behaviors in LPS-induced and CUMS depression models, as shown in the sucrose preference test (SPT), FST, EPM, and novel object recognition test (NORT). Finally, shikonin significantly reduced the levels of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in hippocampus, indicating that the anti-depressant- and anxiolytic-like effects of shikonin are related to the reduction of neuroinflammation in hippocampus. These findings suggest that shikonin exerts anti-depressant- and anxiolytic-like effects via an anti-inflammatory mechanism of shikonin in the hippocampus.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Male
Rats
Antidepressive Agents pharmacology
Antidepressive Agents therapeutic use
Inflammation drug therapy
Behavior, Animal drug effects
Stress, Psychological drug therapy
Stress, Psychological complications
Stress, Psychological psychology
Anti-Anxiety Agents pharmacology
Anti-Anxiety Agents therapeutic use
Lipopolysaccharides
Naphthoquinones pharmacology
Naphthoquinones therapeutic use
Hippocampus drug effects
Hippocampus metabolism
Depression drug therapy
Anxiety drug therapy
Rats, Sprague-Dawley
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 837
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 38997082
- Full Text :
- https://doi.org/10.1016/j.neulet.2024.137893