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Vancomycin-Loaded Sol-Gel System for In Situ Coating of Artificial Bone to Prevent Surgical Site Infections.
- Source :
-
Macromolecular bioscience [Macromol Biosci] 2024 Sep; Vol. 24 (9), pp. e2400078. Date of Electronic Publication: 2024 Jul 16. - Publication Year :
- 2024
-
Abstract
- Surgical site infections (SSIs) related to implants have always been a major challenge for clinical doctors and patients. Clinically, doctors may directly apply antibiotics into the wound to prevent SSIs. However, this strategy is strongly associated with experience of doctors on the amount and the location of antibiotics. Herein, an in situ constructable sol-gel system is developed containing antibiotics during surgical process and validated the efficacy against SSIs in beagles. The system involves chitosan (CS), β-glycerophosphate (β-GP) and vancomycin (VAN), which can be adsorbed onto porous hydroxyapatite (HA) and form VAN-CS/β-GP@HA hydrogel in a short time. The VAN concentration from VAN-CS/β-GP@HA hydrogel is higher than minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus) at the 21st day in vitro. In an in vivo canine model for the prevention of SSIs in the femoral condyle, VAN-CS/β-GP@HA exhibits excellent biocompatibility, antimicrobial properties, and promotion of bone healing. In all, the CS/β-GP instant sol-gel system is able to in situ encapsulate antibiotics and adhere on artificial bone implants during the surgery, effectively preventing SSIs related to implants.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Animals
Dogs
Microbial Sensitivity Tests
Hydrogels chemistry
Hydrogels pharmacology
Phase Transition
Coated Materials, Biocompatible chemistry
Coated Materials, Biocompatible pharmacology
Vancomycin pharmacology
Vancomycin administration & dosage
Vancomycin chemistry
Surgical Wound Infection prevention & control
Chitosan chemistry
Chitosan pharmacology
Staphylococcus aureus drug effects
Glycerophosphates chemistry
Glycerophosphates pharmacology
Durapatite chemistry
Durapatite pharmacology
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1616-5195
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Macromolecular bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 39012275
- Full Text :
- https://doi.org/10.1002/mabi.202400078