Back to Search
Start Over
Lung quantitative ultrasound to stage and monitor interstitial lung diseases.
- Source :
-
Scientific reports [Sci Rep] 2024 Jul 16; Vol. 14 (1), pp. 16350. Date of Electronic Publication: 2024 Jul 16. - Publication Year :
- 2024
-
Abstract
- Chronic interstitial lung diseases (ILDs) require frequent point-of-care monitoring. X-ray-based methods lack resolution and are ionizing. Chest computerized tomographic (CT) scans are expensive and provide more radiation. Conventional ultrasound can detect severe lung damage via vertical artifacts (B-lines). However, this information is not quantitative, and the appearance of B-lines is operator- and system-dependent. Here we demonstrate novel ultrasound-based biomarkers to assess severity of ILDs. Lung alveoli scatter ultrasound waves, leading to a complex acoustic signature, which is affected by changes in alveolar density due to ILDs. We exploit ultrasound scattering in the lung and combine quantitative ultrasound (QUS) parameters, to develop ultrasound-based biomarkers that significantly correlate (pā=ā1e <superscript>-4</superscript> for edema and pā=ā3e <superscript>-7</superscript> for fibrosis) to the severity of pulmonary fibrosis and edema in rodent lungs. These innovative QUS biomarkers will be very significant for monitoring severity of chronic ILDs and response to treatment, especially in this new era of miniaturized and highly portable ultrasound devices.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Humans
Biomarkers analysis
Male
Mice
Pulmonary Fibrosis diagnostic imaging
Pulmonary Fibrosis pathology
Rats
Pulmonary Alveoli diagnostic imaging
Pulmonary Alveoli pathology
Severity of Illness Index
Lung Diseases, Interstitial diagnostic imaging
Lung Diseases, Interstitial pathology
Ultrasonography methods
Lung diagnostic imaging
Lung pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39014011
- Full Text :
- https://doi.org/10.1038/s41598-024-66390-6