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Single intravenous and oral dose pharmacokinetics of the antiseizure medication brivaracetam in healthy cats.
- Source :
-
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2024 Nov; Vol. 47 (6), pp. 461-468. Date of Electronic Publication: 2024 Jul 17. - Publication Year :
- 2024
-
Abstract
- The number of available antiseizure medications with demonstrated efficacy in cats is limited. As such, there is a need to evaluate the pharmacokinetics of newer medications so that proper dosing regimens can be made. Brivaracetam (BRV) is a more potent analogue of levetiracetam, and is Food and Drug Administration approved for use in people. The goal of this study was to describe the pharmacokinetics of intravenous and oral doses of BRV in healthy cats. A cross-over study involving eight healthy cats, that were administered 10 mg of BRV intravenously as a bolus and orally in the fasted state. Blood samples were collected over 24 h. Analysis was performed using liquid chromatography-mass spectrometry. Data were subjected to non-compartmental analysis. Median (min-max) of maximal concentration, time to maximal concentration, area under the curve, elimination half-life and oral absolute bioavailability were 902 (682-1036) ng/mL, 0.6 (0.5-2.0) h, 6.4 (5.2-7.2) h, 8145 (6669-9351) ng × h/mL and 100% (85-110) respectively. BRV appeared to be well tolerated by all cats. A single dose of BRV is well tolerated both orally and intravenously. Maximal concentrations are produced rapidly and within the human reference interval considered to be therapeutic.<br /> (© 2024 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Cats
Administration, Oral
Male
Female
Half-Life
Injections, Intravenous veterinary
Biological Availability
Administration, Intravenous veterinary
Pyrrolidinones pharmacokinetics
Pyrrolidinones administration & dosage
Anticonvulsants pharmacokinetics
Anticonvulsants administration & dosage
Anticonvulsants blood
Cross-Over Studies
Area Under Curve
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2885
- Volume :
- 47
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of veterinary pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 39018069
- Full Text :
- https://doi.org/10.1111/jvp.13473