Targeting TRPM channels for cerebral ischemia-reperfusion injury.

Authors :: Liu DQ
Mei W
Zhou YQ
Xi H
Source :: Trends in pharmacological sciences [Trends Pharmacol Sci] 2024 Jul 16. Date of Electronic Publication: 2024 Jul 16.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: Transient receptor potential melastatin (TRPM) channels have emerged as potential therapeutic targets for cerebral ischemia-reperfusion (I/R) injury. We highlight recent findings on the involvement of TRPM channels in oxidative stress, mitochondrial dysfunction, inflammation, and calcium overload. We also discuss the challenges and future directions in targeting TRPM channels for cerebral I/R injury.<br />Competing Interests: Declaration of interests No interests are declared.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)