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Differentiated metabolomic profiling reveals plasma amino acid signatures for primary glomerular disease.
- Source :
-
Amino acids [Amino Acids] 2024 Jul 18; Vol. 56 (1), pp. 46. Date of Electronic Publication: 2024 Jul 18. - Publication Year :
- 2024
-
Abstract
- Primary glomerular disease (PGD) is an idiopathic cause of renal glomerular lesions that is characterized by proteinuria or hematuria and is the leading cause of chronic kidney disease (CKD). The identification of circulating biomarkers for the diagnosis of PGD requires a thorough understanding of the metabolic defects involved. In this study, ultra-high performance liquid chromatography-tandem mass spectrometry was performed to characterize the amino acid (AA) profiles of patients with pathologically diagnosed PGD, including minimal change disease (MCD), focal segmental glomerular sclerosis (FSGS), membranous nephropathy, and immunoglobulin A nephropathy. The plasma concentrations of asparagine and ornithine were low, and that of aspartic acid was high, in patients with all the pathologic types of PGD, compared to healthy controls. Two distinct diagnostic models were generated using the differential plasma AA profiles using logistic regression and receiver operating characteristic analyses, with areas under the curves of 1.000 and accuracies up to 100.0% in patients with MCD and FSGS. In conclusion, the progression of PGD is associated with alterations in AA profiles, The present findings provide a theoretical basis for the use of AAs as a non-invasive, real-time, rapid, and simple biomarker for the diagnosis of various pathologic types of PGD.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Male
Adult
Middle Aged
Glomerulosclerosis, Focal Segmental blood
Glomerulosclerosis, Focal Segmental diagnosis
Nephrosis, Lipoid blood
Nephrosis, Lipoid diagnosis
Glomerulonephritis, Membranous blood
Glomerulonephritis, Membranous diagnosis
Tandem Mass Spectrometry
Chromatography, High Pressure Liquid
Glomerulonephritis, IGA blood
Glomerulonephritis, IGA diagnosis
Kidney Glomerulus metabolism
Kidney Glomerulus pathology
Amino Acids blood
Metabolomics methods
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 1438-2199
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Amino acids
- Publication Type :
- Academic Journal
- Accession number :
- 39019998
- Full Text :
- https://doi.org/10.1007/s00726-024-03407-4