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Interleukin-24: A molecular mediator of particulate matter's impact on skin aging.
- Source :
-
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Sep 01; Vol. 282, pp. 116738. Date of Electronic Publication: 2024 Jul 18. - Publication Year :
- 2024
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Abstract
- Air pollution, a global health concern, has been associated with adverse effects on human health. In particular, particulate matter (PM), which is a major contributor to air pollution, impacts various organ systems including the skins. In fact, PM has been suggested as a culprit for accelerating skin aging and pigmentation. In this study, using single-cell RNA sequencing, IL-24 was found to be highly upregulated among the differentially expressed genes commonly altered in keratinocytes and fibroblasts of ex vivo skins exposed to PM. It was verified that PM exposure triggered the expression of IL-24 in keratinocytes, which subsequently led to a decrease in type I procollagen expression and an increase in MMP1 expression in fibroblasts. Furthermore, long-term treatment of IL-24 induced cellular senescence in fibroblasts. Through high-throughput screening, we identified chemical compounds that inhibit the IL-24-STAT3 signaling pathway, with lovastatin being the chosen candidate. Lovastatin not only effectively reduced the expression of IL24 induced by PM in keratinocytes but also exhibited a capacity to restore the decrease in type I procollagen and the increase in MMP1 caused by IL-24 in fibroblasts. This study provides insights into the significance of IL-24, illuminating mechanisms behind PM-induced skin aging, and proposes IL-24 as a promising target to mitigate PM-associated skin aging.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Cellular Senescence drug effects
Signal Transduction drug effects
Matrix Metalloproteinase 1 genetics
Matrix Metalloproteinase 1 metabolism
STAT3 Transcription Factor metabolism
Skin drug effects
Air Pollutants toxicity
Skin Aging drug effects
Particulate Matter toxicity
Interleukins metabolism
Interleukins genetics
Keratinocytes drug effects
Fibroblasts drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2414
- Volume :
- 282
- Database :
- MEDLINE
- Journal :
- Ecotoxicology and environmental safety
- Publication Type :
- Academic Journal
- Accession number :
- 39029221
- Full Text :
- https://doi.org/10.1016/j.ecoenv.2024.116738