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Abnormalities in static and dynamic intrinsic neural activity and neurotransmitters in first-episode OCD.
- Source :
-
Journal of affective disorders [J Affect Disord] 2024 Oct 15; Vol. 363, pp. 609-618. Date of Electronic Publication: 2024 Jul 17. - Publication Year :
- 2024
-
Abstract
- Background: Obsessive-compulsive disorder (OCD) is a disabling disorder in which the temporal variability of regional brain connectivity is not well understood. The aim of this study was to investigate alterations in static and dynamic intrinsic neural activity (INA) in first-episode OCD and whether these changes have the potential to reflect neurotransmitters.<br />Methods: A total of 95 first-episode OCD patients and 106 matched healthy controls (HCs) were included in this study. Based on resting-state functional magnetic resonance imaging (rs-fMRI), the static and dynamic local connectivity coherence (calculated by static and dynamic regional homogeneity, sReHo and dReHo) were compared between the two groups. Furthermore, correlations between abnormal INA and PET- and SPECT-derived maps were performed to examine specific neurotransmitter system changes underlying INA abnormalities in OCD.<br />Results: Compared with HCs, OCD showed decreased sReHo and dReHo values in left superior, middle temporal gyrus (STG/MTG), left Heschl gyrus (HES), left putamen, left insula, bilateral paracentral lobular (PCL), right postcentral gyrus (PoCG), right precentral gyrus (PreCG), left precuneus and right supplementary motor area (SMA). Decreased dReHo values were also found in left PoCG, left PreCG, left SMA and left middle cingulate cortex (MCC). Meanwhile, alterations in INA present in brain regions were correlated with dopamine system (D2, FDOPA), norepinephrine transporter (NAT) and the vesicular acetylcholine transporter (VAChT) maps.<br />Conclusion: Static and dynamic INA abnormalities exist in first-episode OCD, having the potential to reveal the molecular characteristics. The results help to further understand the pathophysiological mechanism and provide alternative therapeutic targets of OCD.<br />Competing Interests: Declaration of competing interest All authors declared no conflict of interests.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Male
Female
Adult
Young Adult
Positron-Emission Tomography
Brain physiopathology
Brain diagnostic imaging
Tomography, Emission-Computed, Single-Photon
Case-Control Studies
Brain Mapping
Cerebral Cortex physiopathology
Cerebral Cortex diagnostic imaging
Cerebral Cortex metabolism
Obsessive-Compulsive Disorder physiopathology
Obsessive-Compulsive Disorder diagnostic imaging
Magnetic Resonance Imaging
Neurotransmitter Agents metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 363
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 39029696
- Full Text :
- https://doi.org/10.1016/j.jad.2024.07.123