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Predictive value of CXCL1 + _FAP + phenotype in CAFs for distant metastasis and its correlation with PD-L1 expression in locoregionally advanced nasopharyngeal carcinoma patients.
- Source :
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Oral oncology [Oral Oncol] 2024 Oct; Vol. 157, pp. 106963. Date of Electronic Publication: 2024 Jul 19. - Publication Year :
- 2024
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Abstract
- Objective: There is a lack of effective biomarkers for predicting the distant metastasis in nasopharyngeal carcinoma (NPC). We aimed to explore the expression of FAP <superscript>+</superscript> Cancer-associated fibroblasts (CAFs) derived CXCL1 in NPC and its predictive values for distant metastasis and correlation with PD-L1 expression.<br />Materials and Methods: A total of 345 patients with locoregionally advanced NPC were retrospectively enrolled (the training cohort: the validation cohort = 160:185). Co-expression of CXCL1 and FAP and the expression of PD-L1 were detected by multi-immunofluorescence staining and immunohistochemistry, respectively. The primary end-point was distant metastasis-free survival (DMFS). The Kaplan-Meier method was used to calculate the survival. The Cox proportional hazards model was used to assess prognostic risk factors.<br />Results: A novel CXCL1 <superscript>+</superscript> &#95;FAP <superscript>+</superscript> phenotype in CAFs was identified in NPC and then used to divide patients into low and high risk groups. Both in the training cohort and validation cohort, patients in the high risk group had poorer DMFS, overall survival (OS), progression-free survival (PFS) and locoregional relapse-free survival (LRFS) than patients in the low risk group. Multivariate analysis revealed CXCL1 <superscript>+</superscript> &#95;FAP <superscript>+</superscript> phenotype was an independent prognostic factor for DMFS, OS, PFS and LRFS. Further results showed patients in the high risk group had higher PD-L1 expression than those in the low risk group.<br />Conclusion: Our study showed CXCL1 <superscript>+</superscript> &#95;FAP <superscript>+</superscript> phenotype in CAFs could effectively classified locoregionally advanced NPC patients into different risk groups for distant metastasis and might be a potential biomarker for anti-PD-1/PD-L1 immunotherapy.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Retrospective Studies
Neoplasm Metastasis
Prognosis
Phenotype
Biomarkers, Tumor metabolism
Aged
Serine Endopeptidases metabolism
Endopeptidases metabolism
Membrane Proteins metabolism
B7-H1 Antigen metabolism
Nasopharyngeal Carcinoma metabolism
Nasopharyngeal Carcinoma pathology
Nasopharyngeal Carcinoma mortality
Nasopharyngeal Neoplasms metabolism
Nasopharyngeal Neoplasms pathology
Nasopharyngeal Neoplasms mortality
Chemokine CXCL1 metabolism
Cancer-Associated Fibroblasts metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0593
- Volume :
- 157
- Database :
- MEDLINE
- Journal :
- Oral oncology
- Publication Type :
- Academic Journal
- Accession number :
- 39032343
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2024.106963